HCID 68814364, compound → HCID 68814439, compound

HRID 1436715Notes

Reaction equation

HRID 1436715 reaction equation
C([O:8][C:9](=[O:29])[C:10]1[CH:22]=[C:21]([C:23]2[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=2)[CH:20]=[C:12]([C:13]([N:15]([CH3:19])[CH2:16][CH2:17][CH3:18])=[O:14])[CH:11]=1)C1C=CC=CC=1>[Pd].CO>[CH3:19][N:15]([CH2:16][CH2:17][CH3:18])[C:13](=[O:14])[C:12]1[CH:11]=[C:10]([CH:22]=[C:21]([C:23]2[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=2)[CH:20]=1)[C:9]([OH:29])=[O:8]

Participants

4

Reactant 1

HCID 68814364HCID 68814364, compound

Product 1

HCID 68814439HCID 68814439, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Stir a mixture of N-methyl-N-propyl-5-pyridin-4-yl-isophthalamic acid benzyl ester (1.900 g, 4.891 mmol), 10% palladium on carbon (0.208 g) in MeOH (50 mL) under an atmosphere of hydrogen gas (1 atm) for 0.5 h. Filter through a filtering agent and concentrate to give the title compound (quantitative yield).

Workup

  1. filtrationFilter through a filtering agent
  2. concentrationconcentrate

Sources & evidence

ORD record
ord-1835fdb5bcd241aebc428a49a5f43d6b
Source dataset
uspto-grants-2009_11
Patent number
US07618978B2

Reaction notes

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