反应详情

Dissolve 5-bromo-3-dibenzylamino-2-fluorobenzoic acid (1.53 g, 3.69 mmol) in ethanol (40 mL). Add concentrated sulfuric acid (0.2 mL) as a catalyst and heat to at reflux for 1 day. Cool to room temperature and concentrate. Dissolve the residue in diethyl ether (30 mL) and wash with 10% aqueous potassium carbonate solution (10 mL) and water (10 mL). Dry (magnesium sulfate) and concentrate to give the title compound as an oil (1.50 g, 92%).

1. temperatureheat
2. temperatureto at reflux for 1 day
3. concentrationconcentrate
4. dissolutionDissolve the residue in diethyl ether (30 mL)
5. washwash with 10% aqueous potassium carbonate solution (10 mL) and water (10 mL)
6. dry with materialDry (magnesium sulfate)
7. concentrationconcentrate