関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Fluoride | HCID 522689 | — |
| 反応物 | 5-Nitropent-1-ene | HCID 534297 | — |
| 反応物 | (alphaS)-alpha-[Bis(phenylmethyl)amino]benzenepropanal | HCID 9883943 | — |
| 反応物 | 4-[[1-(Anthracen-9-ylmethyl)-5-ethenyl-1-azoniabicyclo[2.2.2]octan-2-yl]-prop-2-enoxymethyl]quinoline;bromide | HCID 22324578 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (2S,3S)-2-dibenzylamino-4-nitro-1-phenyloct-7-en-3-ol | HCID 69018478 | — |
反応手順
Cool to −10° C. a well stirred mixture of O-allyl-N-(9-anthracenylmethyl)-cinchonidinium bromide (0.480 g, 0.8 mmol), potassium fluoride (3 gr, 51 mmol), THF (150 mL) and 5-nitropent-1-ene (2.34 g, 20 mmol) and treat with a solution of (S)-2-dibenzylamino-3-phenylpropionaldehyde (2.640 gr, 8 mmol). Allow mixture to warn to room temperature and stir for two days. Concentrate under reduced pressure. Purify on silica gel with hexane/ethyl ether mixtures to give a mixture of two products (2.7 g, 75%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07618978B2 |
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| 出典データセット | uspto-grants-2009_11 |
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| ORD ID | ord-a6fd4c4b937841c494c7c56abd2d9158 |
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| 出典メモ | uspto-grants-2009_11 |
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