Dimethyl Sulfoxide → HCID 86615381, compound

Participants

Reaction Steps

Add sulfur trioxide pyridine complex (0.27 g, 1.7 mmol) in dimethylsulfoxide (0.95 mL, 13.0 mmol) to (2R, 5R)-5-Benzyloxy-2-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester (0.27 g, 0.84 mmol) in triethylamine (0.70 mL, 5.0 mmol) at 10° C. and stir at room temperature for 30 minutes. Quench with water and extract with diethyl ether. Combine the organic layers, wash with 5% aqueous citric acid followed by saturated aqueous sodium chloride, dry over magnesium sulfate and concentrate. The residue may be used without further purification.

Provenance & Evidence