Tetrabutylammonium Fluoride → HCID 86615383, compound

Participants

Reaction Steps

Add tetrabutylammonium fluoride (0.08 mL, 0.08 mmol, 1.0 M in tetrahydro-furan) to (2R, 5R)-5-Benzyloxy-2-formyl-piperidine-1-carboxylic acid tert-butyl ester (0.27 mg, 0.84 mmol) and 1,3-difluoro-5-(2-nitro-ethyl)-benzene (0.17 g, 0.93 mmol) in 5 mL tetrahydrofuran. Stir at room temperature overnight and concentrate. Subject the residue to silica gel chromatography, eluting with from 100% hexane to 90:10 hexane:ethyl acetate to provide the desired compound as a mixture of 3 isomers (0.286 g, 67%).

Provenance & Evidence