Sodium ion → 6-[[[1-[2-(5,7-difluoro-2-oxoquinolin-1-yl)ethyl]-3-hydroxypiperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one

HRID 143679Notes

Reaction equation

HRID 143679 reaction equation
[C:37]([O:38][BH-:39]([O:40][C:41](=[O:42])[CH3:43])[O:44][C:45](=[O:46])[CH3:47])(=[O:48])[CH3:49].[NH2:1][CH:2]1[CH:3]([OH:23])[CH2:4][N:5]([CH2:8][CH2:9][n:10]2[c:11](=[O:22])[cH:12][cH:13][c:14]3[c:15]([F:21])[cH:16][c:17]([F:20])[cH:18][c:19]23)[CH2:6][CH2:7]1.[Na+:50].[O:24]=[C:25]1[NH:26][c:27]2[c:28]([cH:31][cH:32][c:33]([CH:35]=[O:36])[n:34]2)[O:29][CH2:30]1>>[NH:1]([CH:2]1[CH:3]([OH:23])[CH2:4][N:5]([CH2:8][CH2:9][n:10]2[c:11](=[O:22])[cH:12][cH:13][c:14]3[c:15]([F:21])[cH:16][c:17]([F:20])[cH:18][c:19]23)[CH2:6][CH2:7]1)[CH2:35][c:33]1[cH:32][cH:31][c:28]2[c:27]([n:34]1)[NH:26][C:25](=[O:24])[CH2:30][O:29]2

Participants

5

Reactant 4

HCID 923Sodium ionHCID 2724942TriacetoxyborohydrideHCID 218737373-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-6-carbaldehydeHCID 670651931-[2-(4-Amino-3-hydroxypiperidin-1-yl)ethyl]-5,7-difluoroquinolin-2-one

Product 1

HCID 732114466-[[[1-[2-(5,7-difluoro-2-oxoquinolin-1-yl)ethyl]-3-hydroxypiperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one

Sources & evidence

ORD record
ord-ca9f4f38783442fb9bd80f24c53d935a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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