反应详情

tert-Butyl ((1 R,3S)-3-isopropyl-3- {[5-(trifluoromethyl)-3′,6′-dihydro-3 ,4′-bipyridin-1′-(2′H)-yl]carbonyl}cyclopentyl)carbamate (24.0 mg, 0.0498 mmol) was dissolved in a 4 M solution of HCl in 1,4-dioxane (2.0 mL) to form a light yellow clear solution. After being stirred at room temperature for 1 h, the reaction mixture was concentrated in vacuo. The residue was treated with a 1 M solution of NaOH and the solution was extracted with methylene chloride three times. The extracts were dried, filtered and concentrated to provide 28 mg of product as a light yellow solid. LC-MS calculated for C20H26F3N3O:(M+H) 382; found 382.1.

1. customto form a light yellow clear solution
2. concentrationthe reaction mixture was concentrated in vacuo
3. additionThe residue was treated with a 1 M solution of NaOH
4. extractionthe solution was extracted with methylene chloride three times
5. customThe extracts were dried
6. filtrationfiltered
7. concentrationconcentrated