HCID 68927819, compound → HCID 57938748, compound

Participants

Reaction Steps

(4R)-N-((1 R,3S)-3-Isopropyl-3-[4-[3-(trifluoromethyl)phenyl] -3,6-dihydropyridin-1(2H)-yl]carbonylcyclopentyl)-3-methoxytetrahydro-2H-pyran-4-amine (8.0 mg, 0.016 mmol) was dissolved in methanol (0.63 mL), degassed-purged with N2, followed by the addition of Palladium (3.44 mg) (10% dry weight on wet activated carbon). The reaction flask was degassed-purged with N2 three times, then stirred at room temperature under H2 (1 atm) overnight. The mixture was filtered through celite pad, washed with methylene chloride and concentrated to provide the desired product as a white solid (5.7 mg, 71%). LC-MS calculated for C27H40F3N2O3:(M+H) 497.2; found 497.2.

Provenance & Evidence