2-(2-(2-(Dipropylamino)ethyl)-6-nitrophenyl)acetic acid hydrochloride → Ropinirole Hydrochloride

HRID 1436863노트

반응식

HRID 1436863 반응식
[ClH:1].[N+:2]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][CH2:12][N:13]([CH2:17][CH2:18][CH3:19])[CH2:14][CH2:15][CH3:16])[C:6]=1[CH2:20][C:21]([OH:23])=O)([O-])=O>[Pd].CO>[CH3:16][CH2:15][CH2:14][N:13]([CH2:12][CH2:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:5]2[NH:2][C:21](=[O:23])[CH2:20][C:6]=12)[CH2:17][CH2:18][CH3:19].[ClH:1]

참가 물질

4

반응물 1

HCID 135309012-(2-(2-(Dipropylamino)ethyl)-6-nitrophenyl)acetic acid hydrochloride

생성물 1

HCID 68727Ropinirole Hydrochloride

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

2-Nitro-6-[2-(N,N-Di-n-propyl amino)ethyl]phenyl acetic acid hydrochloride (100 g) is dissolved methanol (2000 ml) and then hydrogenated in presence of 10% Palladium on charcoal. The reaction mixture is filtered to obtain clear solution. Methanol is distilled out under vacuum at 50° C. Isopropanol (100 ml) is added to the residue and it is cooled, filtered and washed with isopropanol to obtain light yellow crystalline Ropinirole hydrochloride. The product is dried at 60-70° C. under vacuum. Yield 65-75 g.

후처리

  1. filtrationThe reaction mixture is filtered
  2. customto obtain clear solution
  3. distillationMethanol is distilled out under vacuum at 50° C
  4. additionIsopropanol (100 ml) is added to the residue and it
  5. temperatureis cooled
  6. filtrationfiltered
  7. washwashed with isopropanol

출처 및 근거

ORD 기록
ord-8d9d2df5078a400f9c7a920a129e80e1
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07619095B2

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