反应详情

2-Nitro-6-[2-(N,N-Di-n-propyl amino)ethyl]phenyl acetic acid hydrochloride (100 g) is dissolved methanol (2000 ml) and then hydrogenated in presence of 10% Palladium on charcoal. The reaction mixture is filtered to obtain clear solution. Methanol is distilled out under vacuum at 50° C. Isopropanol (100 ml) is added to the residue and it is cooled, filtered and washed with isopropanol to obtain light yellow crystalline Ropinirole hydrochloride. The product is dried at 60-70° C. under vacuum. Yield 65-75 g.

1. filtrationThe reaction mixture is filtered
2. customto obtain clear solution
3. distillationMethanol is distilled out under vacuum at 50° C
4. additionIsopropanol (100 ml) is added to the residue and it
5. temperatureis cooled
6. filtrationfiltered
7. washwashed with isopropanol