HCID 69061372, compound → HCID 69069391, compound

Participants

Reaction Steps

To a solution of 4-cyano-1-(4-fluorobenzyl)-4-phenyl-1,2,3,4-tetrahydropyridin-2-one (3.98 g, 13.0 mmol) in degassed methanol was added 10% Pd/C (0.8 g). The reaction shaken under an atmosphere of 33 psi of hydrogen for 18 hours. More 10% Pd/C (0.4 g) was added and the mixture was shaken under 45 psi of hydrogen for 48 hours. The mixture was filtered through a bed of celite and the filtrate was concentrated to give the title compound as a white solid. 1H NMR (400 MHz, DMSO-d6) δ 7.55 (d, J=7.7 Hz, 2H), 7.46 (t, J=7.9 Hz, 2H), 7.38 (t, J=7.3 Hz, 1H), 7.28 (t, J=3 Hz, 2H), 7.16 (t, J=2.4 Hz, 2H), 4.58 (s, 2H), 3.44 (m, 1H), 3.25 (m, 1H), 3.07 (q, J=16 Hz, 2H), 2.41 (s, 2H) ppm. ES MS M+1=309.

Provenance & Evidence