HCID 57939448, compound → HCID 57939424, compound

Participants

Reaction Steps

In 17 ml of ethanol was dissolved 1.73 g of trans-1-benzyloxycarbonyl-2-(4-fluoro-2-methylphenyl)-4-propanoylaminopiperidine, and added thereto was 280 mg of palladium-carbon (moisture content of 50.9%), and the mixture was stirred under hydrogen atmosphere at room temperature for 3 hours. The reaction mixture was filtered through Celite, and ethanol was removed by distillation. The residue was purified by NH silica gel column chromatography (chloroform:hexane:ethyl acetate=5:5:2), to give 772 mg of trans-2-(4-fluoro-2-methylphenyl)-4-propanoylaminopiperidine as shown in Table 129 below.

Provenance & Evidence