HCID 57939414, compound → HCID 59735747, compound

Participants

Reaction Steps

In 350 ml of ethanol was dissolved 37.0 g of cis-1-benzyloxycarbonyl-2-(4-fluoro-2-methylphenyl)-4-tert-butoxycarbonylaminopiperidine, and 5.5 g of palladium-carbon (moisture content of 50.9%) was added thereto, and the mixture was stirred under hydrogen atmosphere at room temperature for 2 hours. The reaction mixture was filtered through Celite, and ethanol was removed by distillation, to give 25.8 g of cis-2-(4-fluoro-2-methylphenyl)-4-tert-butoxycarbonylaminopiperidine as shown in Table 132 below.

Provenance & Evidence