Ethanolamine → HCID 68534498, compound

Participants

Reaction Conditions

Reaction Steps

In 21 ml of toluene was dissolved 1.63 g of 1-benzyloxycarbonyl-4-hydroxy-2-(2-methylphenyl)piperidine, added thereto was 973 mg of 1,1′-carbonyldiimidazole, and the mixture was stirred at 60° C. for an hour. To the solution was added 1.21 ml of ethanolamine, and the mixture was stirred at 60° C. for 6 hours. To the reaction mixture was added distilled water, and extracted with chloroform. The organic layer was dried and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:acetone=9:1→chloroform:methanol=19:1), to give 1.34 g of 1-benzyloxycarbonyl-4-(2-hydroxyethylaminocarbonyloxy)-2-(2-methylphenyl)piperidine.

Provenance & Evidence