HCID 68534498, compound → HCID 57939557, compound

HRID 1436911Notes

Reaction equation

HRID 1436911 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([O:17][C:18]([NH:20][CH2:21][CH2:22][OH:23])=[O:19])[CH2:13][CH:12]1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[CH3:30])=O)C1C=CC=CC=1>CO.[C].[Pd]>[OH:23][CH2:22][CH2:21][NH:20][C:18]([O:17][CH:14]1[CH2:15][CH2:16][NH:11][CH:12]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[CH3:30])[CH2:13]1)=[O:19]

Participants

4

Reactant 1

HCID 68534498HCID 68534498, compound

Product 1

HCID 57939557HCID 57939557, compoundYield 98%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

In 30 ml of methanol was dissolved 1.33 g of 1-benzyloxycarbonyl-4-(2-hydroxyethylaminocarbonyloxy)-2-(2-methylphenyl)piperidine, and added thereto was 70 mg of 10% palladium-carbon, and the mixture was stirred at room temperature for 14 hours under hydrogen atmosphere. After insoluble matters were removed by filtration, the filtrate was concentrated, to give 880 mg of 4-(2-hydroxyethylaminocarbonyloxy)-2-(2-methylphenyl)piperidine as shown in Table 135 below.

Workup

  1. additionadded
  2. customAfter insoluble matters were removed by filtration
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-46ab3ad4e0e54709bf5d15b986c1a934
Source dataset
uspto-grants-2009_11
Patent number
US07619092B2

Reaction notes

Loading…