Sodium methanethiolate → HCID 69018301, compound

Participants

Reaction Steps

4 g of sodium thiomethoxide are added at 0-5° C. to a solution of 13.8 g of N-[(1S)-2-chloro-1-(4-methoxybenzyl)ethyl]acetamide in 60 ml of tetra-hydrofuran. After returning to ambient temperature, the suspension is filtered and the solid is washed with 2×10 ml of tetrahydrofuran. The filtrate is concentrated to dryness, providing 14 g of N-[(1S)-1-(4-methoxybenzyl)-2-(methylthio)ethyl]acetamide.

Provenance & Evidence