Benzyl 4-isobutyl-1-piperazinecarboxylate → 1-(2-Methylpropyl)piperazine

HRID 1436980Notes

Reaction equation

HRID 1436980 reaction equation
[CH2:1]([N:5]1[CH2:10][CH2:9][N:8](C(OCC2C=CC=CC=2)=O)[CH2:7][CH2:6]1)[CH:2]([CH3:4])[CH3:3]>C(O)C.[C].[Pd]>[CH2:1]([N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)[CH:2]([CH3:4])[CH3:3]

Participants

4

Reactant 1

HCID 23069811Benzyl 4-isobutyl-1-piperazinecarboxylate

Product 1

HCID 20520521-(2-Methylpropyl)piperazineYield 112.9%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

The resulting benzyl 4-isobutylpiperazin-1-carboxylate (1.05 g) was dissolved in 35 mL of ethanol, 10% palladium-carbon (750 mg) was added thereto, and the reaction mixture was stirred at room temperature under hydrogen atmosphere (1 atm) for 12 hours. The palladium-carbon was removed by filtration, and the filtrate was evaporated to give the title compound (610 mg) as a colorless oil.

Workup

  1. customThe palladium-carbon was removed by filtration
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-cc9eeca2b89941d9a07e07a2c5c939e8
Source dataset
uspto-grants-2009_11
Patent number
US07619100B2

Reaction notes

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