HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylpiperazine → 8-Chloro-11-(3-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylpiperazine | HCID 66057 | — |
| Reactant | 8-chloro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one | HCID 3653116 | — |
| Product | 8-Chloro-11-(3-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine | HCID 135409777 | 91.8% |
Reaction Steps
8-Chloro-5,10-dihydro-dibenzo[b,e][1,4]diazepine-11-one (25 mg, 0.1 mmol) and 2-methylpiperazine (100 mg, 1.0 mmol) were reacted according to GP4 to give 30 mg of the title compound (160FE38). MS (ESI) 327 (MH+). Purity for MH+ (UV/MS) 100/89.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622461B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-40fb4bcde3024beeb6c5c3b943894ba5 |
| Source note | uspto-grants-2009_11 |