Morpholine → HCID 135421235, compound

HRID 1437018Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8](SC)=[N:7][C:6]=2[CH:18]=1.[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[N:7][C:6]=2[CH:18]=1

Participants

Reactant 2

HCID 8083Morpholine

HCID 136056013HCID 136056013, compound

Product 1

HCID 135421235HCID 135421235, compoundYield 16.1%

Procedure

Crude 8-chloro-11-methylsulfanyl-5H-dibenzo[b,e][1,4]diazepine (166JO50) (90 mg, purity 50%, 0.218 mmol) and morpholine (38 mg, 0.44 mmol) were reacted as described for Example 62 to give 11 mg of the title compound (166JO69B). MS (ESI) 314 (MH+). Purity for MH+ (UV/MS) 100/98.

Sources & evidence

ORD record: ord-c7973bdbc5654c39b142ece9f79049c5
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07622461B2

Reaction notes

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