HuagongsheHuagongshe Chemistry Print Report · For research reference only
8,5-Dichloro-5H-dibenzo[b,e][1,4]diazepine → 8-Chloro-11-(4-fluorobenzyl)-5H-dibenzo[b,e][1,4]diazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8,5-Dichloro-5H-dibenzo[b,e][1,4]diazepine | HCID 57485431 | — |
| Reactant | HCID 178505764 | HCID 178505764 | — |
| Product | 8-Chloro-11-(4-fluorobenzyl)-5H-dibenzo[b,e][1,4]diazepine | HCID 136029245 | 77.2% |
Reaction Steps
4-Fluorobenzylzinc chloride (0.8 ml, 0.5 M in THF, 0.4 mmol) and 8,5-dichloro-5H-dibenzo[b,e][1,4]diazepine (160FE64) (53 mg, 0.2 mmol) were reacted according GP10 to give 52 mg of the title compound (160FE59). MS (ESI) 337 (MH+). Purity for MH+ (UV/MS) 90/90.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622461B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-9f925a0ffd4247e7b6708ccf0d001bc1 |
| Source note | uspto-grants-2009_11 |