Acetone → HCID 178443599, compound

Participants

Reaction Conditions

Reaction Steps

25 ml of methanol, 40 ml of acetone and 0.1 ml of concentrated hydrochloric acid were added to 16 g (4.6 mmol) of N1-(4-hydroxybenzyl)-N5-octyl-biguanide dihydrochloride, and the mixture was stirred at 40° C. for 63 hours, and refluxed for 8 hours. The solvent was distilled off under reduced pressure, to give a residue, which was dissolved in 80% aqueous acetonitrile. The solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography (elution with a mixture of chloroform and methanol (8:2)) to obtain 16 g of a colorless resinous solid.

Provenance & Evidence