Acetone → HCID 178443328, compound

Participants

Reaction Steps

25 ml of methanol, 40 ml of acetone and 0.1 ml of concentrated hydrochloric acid were added to 2.0 g (4.5 mmol) of N1-(4-hydroxybenzyl)-N5-undecyl-biguanide dihydrochloride, and the mixture was refluxed for 24 hours. The solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography (elution with a mixture of chloroform and methanol (8:1.5)), and then recrystallized with 80% aqueous acetonitrile to obtain 0.73 g of colorless crystals having a melting point of 110 to 112° C.

Provenance & Evidence