Hydrochloric Acid → HCID 69056366, compound

Participants

Reaction Steps

200 ml of n-butanol, 6 ml (67.8 mmol) of methylal and 0.7 ml of concentrated hydrochloric acid were added to 2.5 g (5.6 mmol) of N1-(4-methoxyphenethyl)-N5-decyl-biguanide dihydrochloride, and the mixture was refluxed for 68 hours. The solvent was distilled of f under reduced pressure, and dissolved in 80% aqueous acetonitrile. The solvent was distilled off under reduced pressure to give a residue, which was purified by silica gel column chromatography (elution with a mixture of chloroform/methanol/acetic acid (8:0.7:0.7)) to obtain 0.7 g of a colorless resinous solid.

Provenance & Evidence