Acetone → HCID 178443385, compound

Participants

Reaction Steps

50 ml of methanol, 40 ml of acetone and 0.2 ml of concentrated hydrochloric acid were added to 1.5 g (3.6 mmol) of N1-(4-methoxyphenyl)-N5-decyl-biguanide dihydrochloride, and the mixture was refluxed for 20 hours. The solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography (elution with a mixture of chloroform and methanol (9:1)). The eluate was dissolved in 80% aqueous acetonitrile, and the solvent was distilled off under reduced pressure, followed by sufficient drying under reduced pressure to obtain 0.92 g of a pale yellow resinous solid.

Provenance & Evidence