Hydrochloric Acid → HCID 69054656, compound

Participants

Reaction Steps

100 ml of ethanol, 4.8 ml (27.9 mmol) of 1-nonanal and 0.8 ml of concentrated hydrochloric acid were added to 5.0 g (18.5 mmol) of N1-(4-tert-butylphenyl)-biguanide hydrochloride, and the mixture was refluxed for 15 hours. The solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography (elution with a mixture of chloroform and methanol (9:1.5)), and recrystallized from 70% aqueous acetonitrile to obtain 16 g of colorless crystals having a melting point of 231 to 234° C.

Provenance & Evidence