Hydrochloric Acid → HCID 69063241, compound

Participants

Reaction Steps

100 ml of ethanol, 3.7 g (26.2 mmol) of 1-nonanal and 0.8 ml of concentrated hydrochloric acid were added to 6.0 g (20.0 mmol) of N1-(2-methoxy-5-tert-butylphenyl)-biguanide hydrochloride, and the mixture was refluxed for 20 hours. The solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography (elution with a mixture of chloroform and methanol (9:1.5)). The eluate was dissolved in 80% aqueous ethanol, and the solvent was distilled off under reduced pressure. The residue was recrystallized from ethanol and ether to obtain 2.3 g of pale yellow crystals having a melting point of 217 to 219° C.

Provenance & Evidence