Hydrochloric Acid → HCID 69062795, compound

Participants

Reaction Steps

100 ml of ethanol, 4.7 ml (25.1 mmol) of 1-decanal and 0.7 ml of concentrated hydrochloric acid were added to 5.0 g (16.8 mmol) of N1-(4-trifluoromethoxyphenyl)-biguanide hydrochloride, and the mixture was refluxed for 16 hours. The solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography (elution with a mixture of chloroform and methanol (8:1.5)), and recrystallized from 80% ethanol to obtain 1.1 g of colorless crystals having a melting point of 213 to 215° C.

Provenance & Evidence