Hydrochloric Acid → HCID 69058348, compound

Participants

Reaction Steps

100 ml of ethanol, 5.1 g (29.9 mmol) of 1-undecanal and 0.8 ml of concentrated hydrochloric acid were added to 5.0 g (20.0 mmol) of N1- (2,4-difluorophenyl)-biguanide hydrochloride, and the mixture was refluxed for 8 hours. The solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography (elution with a mixture of chloroform and methanol mixed solution (9:1.5)), and recrystallized from 80% aqueous ethanol to obtain 1.7 g of colorless crystals having a melting point of 207 to 209° C.

Provenance & Evidence