Hydrochloric Acid → HCID 69057082, compound

Participants

Reaction Steps

100 ml of ethanol, 6.6 ml (29.9 mmol) of 1-dodecanal and 0.9 ml of concentrated hydrochloric acid were added to 5.0 g (20.0 mmol) of N1-(2,4-difluorophenyl)-biguanide hydrochloride, and the mixture was refluxed for 20 hours. The solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography (elution with a mixture of chloroform and methanol (9:1.5)), and recrystallized from 70% aqueous acetonitrile to obtain 3.9 g of colorless crystals having a melting point of 206 to 208° C.

Provenance & Evidence