Acetone → HCID 178476233, compound

Participants

Reaction Conditions

Reaction Steps

55 ml of 5N aqueous sodium hydroxide was added to 40 g (92.1 mmol) of N1-(4-methoxybenzyl)-N5-decylbiguanide dihydrochloride in 400 ml of methanol, and the mixture was stirred at 60° C. for 30 minutes. The solvent was distilled off under reduced pressure, and the residue was extracted with chloroform. The extract was washed with water, and the solvent was distilled off under reduced pressure to give a residue, to which were added 450 ml of acetone, 150 ml of methanol and 6.4 ml (46.6 mmol) of piperidine. The mixture was refluxed for 15 hours, and the solvent was distilled off under reduced pressure. The residue was washed with water while stirring, dissolved in ethyl acetate, and washed with water. After removal of the solvent by evaporation under reduced pressure, the residue was dried under reduced pressure to obtain 37 g of a colorless solid (1). Then, 2.3 g (5.9 mmol) of the solid was dissolved in 100 ml of methanol, and 169 g (19.7 mmol) of methanesulfonic acid was added thereto. The solvent was distilled off under reduced pressure, and the residue was dissolved in 70% aqueous acetonitrile. The solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography (elution with a mixture of chloroform and methanol (9:1.5)). Crystallization took place upon addition of ether to obtain 1.9 g of colorless crystals (2) having a melting point of 56 to 58° C.

Provenance & Evidence