Acetone → HCID 178476237, compound

Participants

Reaction Steps

100 ml of methanol, 100 ml of acetone and 0.4 ml of concentrated hydrochloric acid were added to 5.0 g (13.3 mmol) of N1-benzyl-N5-octyl-biguanide dihydrochloride. The mixture was refluxed for 22 hours, and the solvent was distilled off under reduced pressure. The residue was dissolved in 100 ml of ethanol, and to the solution were added 80 ml of water and 5.8 ml of 5N aqueous sodium hydroxide. The mixture was refluxed for 1.5 hours, concentrated under reduced pressure, and extracted with ethyl acetate. The extract was washed with water, and the solvent was distilled off under reduced pressure, and a portion (2.8 g) of 5.8 g of the resulting crystals were recrystallized from ether to obtain 1.1 g of colorless crystals having a melting point of 88 to 91° C.

Provenance & Evidence