Acetone → HCID 178476241, compound

Participants

Reaction Steps

100 ml of methanol, 80 ml of acetone and 0.6 ml of concentrated hydrochloric acid were added to 10.0 g (25.1 mmol) of N1,N5-dioctyl-biguanide dihydrochloride. The mixture was refluxed for 64 hours, and the solvent was distilled off under reduced pressure. To the residue were added 110 ml of ethanol, 60 ml of water and 10.1 ml of 5N sodium hydroxide, and the mixture was refluxed for 1 hour, concentrated under reduced pressure, and then extracted with ethyl acetate. The extract was washed with water, and the solvent was distilled off under reduced pressure. The residue was recrystallized from methyl ethyl ketone to obtain 7.2 g of colorless crystals having a melting point of 91 to 93° C.

Provenance & Evidence