Acetone → HCID 178476242, compound

Participants

Reaction Steps

100 ml of methanol, 80 ml of acetone and 0.5 ml of concentrated hydrochloric acid were added to 8.0 g (20.8 mmol) of N1-octyl-N5-heptyl-biguanide dihydrochloride. The mixture was refluxed for 64 hours, and the solvent was distilled off under reduced pressure. To the residue were added 100 ml of ethanol, 60 ml of water and 8.5 ml of 5N sodium hydroxide, and the mixture was refluxed for 1 hour, concentrated under reduced pressure, and extracted with ethyl acetate. The extract was washed with water, and 1.3 g of acetic acid was added thereto. The solvent was distilled off under reduced pressure, and the residue was dried well, and recrystallized from methyl ethyl ketone to obtain 4.1 g of colorless crystals having a melting point of 82 to 84° C.

Provenance & Evidence