HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formic Acid → HCID 25022847, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | 2,2-Dimethyl-propanoic Acid [3-Chloro-2-[[[2-[(triphenylmethyl)amino]-5-thiazolyl]carbonyl]amino]phenyl]methyl Ester | HCID 25022846 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 25022847 | HCID 25022847 | 87.4% |
Reaction Steps
A mixture of compound 9a (8.90 g, 14 mmol) and formic acid (15 mL, 96% in H2O) in EtOH (150 mL) was refluxed for 24 h. After cooling, the solution was concentrated in vacuo. The residue was subjected to a short column using EtOAc in hexane (30% to 70%) to give the crude compound 10a which was triturated with 10% EtOAc in hexane to give compound 10a (4.50 g, 87% yield). 1H NMR (500 MHz, CDCl3) δ 1.17 (s, 9H), 5.09 (s, 2H), 7.20-7.39 (m, 5H), 8.01 (s, 1H), 8.84 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622473B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-50da69ef0df048c09adb0646ee47fb09 |
| Source note | uspto-grants-2009_11 |