HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1437138Generated: November 1, 2026
Hydrochloric Acid → Ethyl 5-(aminomethyl)-3-isoxazolecarboxylate
https://huagongshe.com/reaction/1437138
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl 5-(aminomethyl)isoxazole-3-carboxylate, 5-BOC protected | HCID 10588096 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Ethyl 5-(aminomethyl)-3-isoxazolecarboxylate | HCID 10850588 | 91.7% |
Reaction Steps
To a stirred solution of 5-(tert-butoxycarbonylaminomethyl)-isoxazole-3-carboxylic acid ethyl ester (1.954 g) (EP 0451790) in ethanol (15 ml) was added a solution of 4.0M hydrogen chloride in 1,4-dioxane (23 ml). The mixture was stirred at 20° C. for 22 h and the solvent evaporated in vacuo to give the title compound (1.128 g) as a pale brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07622464B2 |
|---|
| Source dataset | uspto-grants-2009_11 |
|---|
| ORD ID | ord-679b4847c7f54a819a20d8a5d5e8f9d4 |
|---|
| Source note | uspto-grants-2009_11 |
|---|
