Methyl 2-[[[(phenylmethoxy)carbonyl]amino]methyl]-4-oxazolecarboxylate → Methyl 2-(aminomethyl)oxazole-4-carboxylate

Participants

Reaction Conditions

Reaction Steps

2-(Benzyloxycarbonylaminomethyl)oxazole-4-carboxylic acid methyl ester (0.439 g) (prepared as described in; Journal of Peptide Science (1999), 5(9), 392-398) was dissolved in ethyl acetate (13 ml) and hydrogenated with vigorous stirring at 20° C. and 1 atmosphere of pressure using 10% palladium on carbon catalyst (0.20 g) for 4 hours. The mixture was filtered using celite filter aid and the solvent evaporated from the filtrate in vacuo to give the title compound as a yellow solid (0.197 g)

Provenance & Evidence