HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(1-Bromoethyl)-1,2-difluorobenzene → {(2S)-4-[1-(3,4-Difluoro-phenyl)-ethyl]-morpholin-2-ylmethyl}-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(1-Bromoethyl)-1,2-difluorobenzene | HCID 18980797 | — |
| Reactant | tert-Butyl {(2S)-4-[1-(3,4-dichlorophenyl)ethyl]morpholin-2-yl}methylcarbamate | HCID 86760345 | — |
| Product | {(2S)-4-[1-(3,4-Difluoro-phenyl)-ethyl]-morpholin-2-ylmethyl}-carbamic acid tert-butyl ester | HCID 57940565 | — |
Reaction Steps
Prepared in similar fashion to tert-Butyl {(2S)-4-[1-(3,4-dichlorophenyl)ethyl]morpholin-2-yl}methylcarbamate (as described in WO 02/026723) using (+)-4-(1-bromoethyl)-1,2-difluorobenzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622464B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-5ecdff54e6304c78a9c5dc094485b834 |
| Source note | uspto-grants-2009_11 |