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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1437147Generated: October 27, 2026

1-(2-Methyl-2H-tetrazol-5-yl)methanamine → 1-{(2S)-4-[1-(3,4-Dichlorophenyl)ethyl]morpholin-2-ylmethyl}-3-(2-methyl-2H-tetrazol-5-ylmethyl)urea

https://huagongshe.com/reaction/1437147

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Methyl-2H-tetrazol-5-yl)methanamineHCID 13789252—
Reactant4-nitrophenyl {(2S)-4-[1-(3,4-dichlorophenyl)ethyl]morpholin-2-yl}methylcarbamateHCID 69066802—
Product1-{(2S)-4-[1-(3,4-Dichlorophenyl)ethyl]morpholin-2-ylmethyl}-3-(2-methyl-2H-tetrazol-5-ylmethyl)ureaHCID 57940581—

Reaction Steps

Prepared in similar fashion to Example 16 but using C-(2-methyl-2H-tetrazol-5-yl)-methylamine and 4-nitrophenyl {(2S)-4-[1-(3,4-dichlorophenyl)ethyl]morpholin-2-yl}methylcarbamate Isomer I (prepared as described in WO 02/26723).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07622464B2
Source datasetuspto-grants-2009_11
ORD IDord-df2b96bee0eb4d3eb0ac06a347f062db
Source noteuspto-grants-2009_11