HCID 17973021, compound → HCID 68896902, compound

HRID 1437166Notes

Reaction equation

HRID 1437166 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][N:6]1[C:10]2=[N:11][CH:12]=[CH:13][CH:14]=[C:9]2[C:8]([CH:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)=[CH:7]1)[CH3:2].[CH2:21]([O:23][C:24](=[O:35])[C:25]1[CH:30]=[C:29]([CH2:31]Br)[CH:28]=[CH:27][C:26]=1[O:33][CH3:34])[CH3:22]>>[CH2:21]([O:23][C:24](=[O:35])[C:25]1[CH:30]=[C:29]([CH2:31][N:18]2[CH2:17][CH2:16][CH:15]([C:8]3[C:9]4[C:10](=[N:11][CH:12]=[CH:13][CH:14]=4)[N:6]([CH2:5][CH2:4][O:3][CH2:1][CH3:2])[CH:7]=3)[CH2:20][CH2:19]2)[CH:28]=[CH:27][C:26]=1[O:33][CH3:34])[CH3:22]

Participants

3

Reactant 2

HCID 17973021HCID 17973021, compoundHCID 688939465-Bromomethyl-2-methoxybenzoic acid ethyl ester

Product 1

HCID 68896902HCID 68896902, compound

Procedure

This compound was prepared following the procedure described in example 4, part E, starting with 0.73 g (2.67 mmol) of 1-(2-ethoxyethyl)-3-piperidin-4-yl-1H-pyrrolo[2,3-b]pyridine and 0.88 g (3.20 mmol) of 5-bromomethyl-2-methoxybenzoic acid ethyl ester. After standard work-up and purification, 0.38 g (31% of yield) of the expected product were obtained.

Workup

  1. customThis compound was prepared
  2. customAfter standard work-up and purification, 0.38 g (31% of yield) of the expected product
  3. customwere obtained

Sources & evidence

ORD record
ord-f5ac5f125c9b4da188c1ece295d945d6
Source dataset
uspto-grants-2009_11
Patent number
US07622480B2

Reaction notes

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