Methyl 2-(2-chloroethoxy)benzoate → HCID 68894902, compound

HRID 1437167Notes

Reaction equation

HRID 1437167 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][N:6]1[C:10]2=[N:11][CH:12]=[CH:13][CH:14]=[C:9]2[C:8]([CH:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)=[CH:7]1)[CH3:2].[CH3:21][O:22][C:23](=[O:34])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[O:30][CH2:31][CH2:32]Cl>>[CH3:21][O:22][C:23](=[O:34])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[O:30][CH2:31][CH2:32][N:18]1[CH2:17][CH2:16][CH:15]([C:8]2[C:9]3[C:10](=[N:11][CH:12]=[CH:13][CH:14]=3)[N:6]([CH2:5][CH2:4][O:3][CH2:1][CH3:2])[CH:7]=2)[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 9837283Methyl 2-(2-chloroethoxy)benzoateHCID 17973021HCID 17973021, compound

Product 1

HCID 68894902HCID 68894902, compound

Procedure

This compound was prepared following the procedure described in example 4, part E, starting with 0.98 g (3.58 mmol) of 1-(2-ethoxyethyl)-3-piperidin-4-yl-1H-pyrrolo[2,3-b]pyridine and 0.92 g (4.29 mmol) of 2-(2-chloroethoxy)benzoic acid methyl ester. After standard work-up and purification, 0.58 g (36% of yield) of the expected product were obtained.

Workup

  1. customThis compound was prepared
  2. customAfter standard work-up and purification, 0.58 g (36% of yield) of the expected product
  3. customwere obtained

Sources & evidence

ORD record
ord-53096ed933ec4141bef6a5eae74f2102
Source dataset
uspto-grants-2009_11
Patent number
US07622480B2

Reaction notes

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