3-(Bromomethyl)thiophene → HCID 68895206, compound

HRID 1437176Notes

Reaction equation

HRID 1437176 reaction equation
C(OC(N1CCC([C:14]2[C:22]3[C:17](=[N:18][CH:19]=[CH:20][CH:21]=3)[NH:16][CH:15]=2)CC1)=O)(C)(C)C.Br[CH2:24][C:25]1[CH:29]=[CH:28][S:27][CH:26]=1>C(OCC)C>[N:18]1([C:14]2[C:22]3[C:17](=[N:18][CH:19]=[CH:20][CH:21]=3)[N:16]([CH2:24][C:25]3[CH:29]=[CH:28][S:27][CH:26]=3)[CH:15]=2)[CH2:19][CH2:20][CH2:21][CH2:22][CH2:17]1

Participants

4

Reactant 2

HCID 5207033-(Bromomethyl)thiopheneHCID 49758876tert-butyl 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)piperidine-1-carboxylate

Product 1

HCID 68895206HCID 68895206, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

This compound was prepared following the procedure described in example 7, parts E and F, starting with 0.3 g (1 mmol) of 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-piperidine-1-carboxylic acid tert-butyl ester and 2.12 ml of a freshly prepared 0.61 M solution of 3-bromomethylthiophene in ethyl ether. After standard work-up, 0.39 g (100% of yield) of the expected product were isolated.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-61049fa448ca4b37beacb73f3c1739b1
Source dataset
uspto-grants-2009_11
Patent number
US07622480B2

Reaction notes

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