反应详情

Over a solution of 2.86 g (6.6 mmol) of 4-[1-(5-chlorothiophen-2-ylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-piperidine-1-carboxylic acid tert-butyl ester in 20 ml of dichloromethane, 5.1 ml of trifluoroacetic acid were added. After 1 hour at room temperature, the solvent was removed under reduced pressure. The crude mixture was dissolved in ethyl acetate and washed with saturated solution of potassium carbonate and brine. The organic phase was dried over magnesium sulphate, filtered and removed under reduced pressure affording 2.8 g of a crude mixture which was pure enough for the next synthetic step.

1. customthe solvent was removed under reduced pressure
2. dissolutionThe crude mixture was dissolved in ethyl acetate
3. washwashed with saturated solution of potassium carbonate and brine
4. dry with materialThe organic phase was dried over magnesium sulphate
5. filtrationfiltered
6. customremoved under reduced pressure