Potassium Hydroxide → 1-furan-3-ylmethyl-3-piperidinyl-1H-pyrrolo[2,3-b]pyridine

HRID 1437189Notes

Reaction equation

HRID 1437189 reaction equation
C(OC(N1CCC([C:12]2[C:20]3[C:15](=[N:16][CH:17]=[CH:18][CH:19]=3)[N:14]([CH2:21][C:22]3[CH:26]=[CH:25][O:24][CH:23]=3)[CH:13]=2)CC1)=O)C.[OH-].[K+]>>[O:24]1[CH:25]=[CH:26][C:22]([CH2:21][N:14]2[C:15]3=[N:16][CH:17]=[CH:18][CH:19]=[C:20]3[C:12]([N:16]3[CH2:17][CH2:18][CH2:19][CH2:20][CH2:15]3)=[CH:13]2)=[CH:23]1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 688947724-(1-furan-3-ylmethyl-1H-pyrrolo[2,3-b]pyridin-3-yl) piperidine-1-carboxylic acid ethyl ester

Product 1

HCID 688947451-furan-3-ylmethyl-3-piperidinyl-1H-pyrrolo[2,3-b]pyridineYield 248.8%

Procedure

This compound was prepared following the procedure described in example 24, part D, starting with 4.44 g (11 mmol) of 4-(1-furan-3-ylmethyl-1H-pyrrolo[2,3-b]pyridin-3-yl) piperidine-1-carboxylic acid ethyl ester and 3.6 g of potassium hydroxide. After standard work-up, 3.85 g of 1-furan-3-ylmethyl-3-piperidinyl-1H-pyrrolo[2,3-b]pyridine were obtained.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-01a7a8dcfd914678b18736c4bff2829c
Source dataset
uspto-grants-2009_11
Patent number
US07622480B2

Reaction notes

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