Methyl 2-(2-chloroethoxy)benzoate → HCID 68893951, compound

HRID 1437199Notes

Reaction equation

HRID 1437199 reaction equation
[CH2:1]([N:5]1[C:9]2=[CH:10][N:11]=[CH:12][CH:13]=[C:8]2[C:7](N2CCCCC2)=[CH:6]1)[CH2:2][CH2:3][CH3:4].[CH3:20][O:21][C:22](=[O:33])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[O:29][CH2:30][CH2:31]Cl>>[CH3:20][O:21][C:22](=[O:33])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[O:29][CH2:30][CH2:31][N:11]1[CH2:12][CH2:13][CH:8]([C:7]2[C:8]3[C:9](=[CH:10][N:11]=[CH:12][CH:13]=3)[N:5]([CH2:1][CH2:2][CH2:3][CH3:4])[CH:6]=2)[CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 9837283Methyl 2-(2-chloroethoxy)benzoateHCID 68894742HCID 68894742, compound

Product 1

HCID 68893951HCID 68893951, compoundYield 96.2%

Procedure

This compound was prepared following the procedure described in example 4, part E, starting with 1.35 g (5.25 mmol) of 1-butyl-3-piperidin yl-1H-pyrrolo[2,3-c]pyridine and 1.35 g (6.3 mmol) of 2-(2-chloroethoxy)benzoic acid methyl ester. After standard work-up and purification, 1.1 g (49% yield) of 2-{2-[4-(1-butyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-piperidin-1-yl]-ethoxy}-benzoic acid methyl ester were obtained.

Workup

  1. customThis compound was prepared
  2. customAfter standard work-up and purification

Sources & evidence

ORD record
ord-46f5eca6f17048d7b8e8e5035792756b
Source dataset
uspto-grants-2009_11
Patent number
US07622480B2

Reaction notes

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