Hydrochloric Acid → HCID 23090224, compound

Participants

Reaction Steps

1N Aqueous solution of sodium hydroxide (2.23 mL) was added to 1-(6-Methoxy-3-pyridyl)-5-(4-methoxy-2-pyridyl)pyrazole-3-carboxylic acid ethyl ester (0.416 g) obtained from Referential Example 18 in a mixture of methanol (6.3 mL) and tetrahydrofuran (6.3 mL) at room temperature, followed by stirring for 5 hours. The reaction mixture was neutralized with 1N aqueous solution of hydrochloric acid (2.23 mL), and then partitioned between water and chloroform. Subsequently, the aqueous layer was extracted with chloroform twice. The organic layer was dried over sodium sulfate anhydrate, followed by filtration. The solvent was evaporated under reduced pressure, to thereby give the title compound as a solid substance (0.353 g, 92%).

Provenance & Evidence