2-Ethenyl-5-nitropyridine → 6-Ethylpyridin-3-amine

HRID 1437216Notes

Reaction equation

HRID 1437216 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH:10]=[CH2:11])=[N:8][CH:9]=1)([O-])=O.[H][H]>C(O)C.[C].[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH3:11])=[N:8][CH:9]=1

Participants

5

Reactant 2

HCID 230905502-Ethenyl-5-nitropyridineHCID 178418361HCID 178418361, compound

Product 1

HCID 138607296-Ethylpyridin-3-amine

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

10% Palladium-carbon (50% wet, 90 mg) was added to 5-nitro-2-vinylpyridine (450 mg) in ethanol (30 mL), followed by stirring in a hydrogen atmosphere at room temperature for 15 hours. The catalyst was removed from the reaction mixture by filtration. Subsequently, the solvent was evaporated under reduced pressure, to thereby give the title compound as an oily substance (359 mg, 98%).

Workup

  1. customThe catalyst was removed from the reaction mixture by filtration
  2. customSubsequently, the solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-a416115830cf4a28b2528ea5ae593b4e
Source dataset
uspto-grants-2009_11
Patent number
US07622471B2

Reaction notes

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