rel-(2R,6S)-2,6-dimethylpiperazine → Tert-butyl 3,5-dimethylpiperazine-1-carboxylate

Participants

Reaction Steps

cis-2,6-Dimethylpiperazine (5.08 g) was added to 2-(tert-butoxycarbonylimino)-2-phenylacetonitrile (11.35 g) in tetrahydrofuran (150 mL) at 0° C., followed by stirring for 2 hours. The reaction solvent was evaporated under reduced pressure. The residue was purified through silica gel column chromatography (chloroform−7N ammonia/methanol mixture), to thereby give the title compound (15.36 g, 72%).

Provenance & Evidence