1,4-Dioxane hydrochloride → HCID 22061382, compound

HRID 1437231Notes

Reaction equation

HRID 1437231 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][O:16][CH3:17])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:18].O1CCOCC1>>[ClH:18].[CH3:17][O:16][CH2:15][CH2:14][N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 60043433HCID 60043433, compound

Product 1

HCID 22061382HCID 22061382, compoundYield 74%

Procedure

1-(2-Methoxyethyl)piperazine-4-carboxylic acid tert-butyl ester (1.39 g) obtained from Referential Example 96 was dissolved in 4N HCl-dioxane (20 mL). The resultant solution was stirred at room temperature for 3 hours. The solvent of the reaction mixture was evaporated under reduced pressure, and ethanol was added to the residue, and then the solvent of the resultant mixture was evaporated. Ethanol and ether were added to the residue, and the precipitated solid was recovered by filtration, to thereby give the title compound (900 mg, 74%).

Workup

  1. customThe solvent of the reaction mixture was evaporated under reduced pressure, and ethanol
  2. additionwas added to the residue
  3. customthe solvent of the resultant mixture was evaporated
  4. additionEthanol and ether were added to the residue
  5. filtrationthe precipitated solid was recovered by filtration

Sources & evidence

ORD record
ord-ed0b932e75ed4d45b285ca2134aab8cf
Source dataset
uspto-grants-2009_11
Patent number
US07622471B2

Reaction notes

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