HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonyl chloride → 1-(Diphenylmethyl)azetidin-3-yl methanesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 1-(Diphenylmethyl)azetidin-3-ol | HCID 330448 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 1-(Diphenylmethyl)azetidin-3-yl methanesulfonate | HCID 2758716 | 45% |
Reaction Steps
Under cooling with ice, methanesulfonyl chloride (0.68 mL) was added dropwise to 1-benzhydrylazetidin-3-ol (1.50 g) in pyridine (12 mL), followed by stirring at room temperature overnight. Ice-water was added to the reaction mixture, and the precipitated material was recovered by filtration, to thereby give the title compound (890 mg, 45%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622471B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-568b71922fc741d19121e0a1082a49f6 |
| Source note | uspto-grants-2009_11 |