Hydrazine hydrate (1:1) → 5-Bromo-2-hydrazinopyridine

Participants

Reaction Steps

Hydrazine monohydrate (10 mL) was added to 2,5-dibromopyridine (10.0 g) in pyridine (100 mL) at room temperature, and the resultant mixture was refluxed under heat for 13 hours, and then cooled in air. The reaction solvent was removed under reduced pressure, and the residue was partitioned by use of aqueous 0.5N sodium hydroxide and chloroform. The organic layer was dried over sodium sulfate anhydrate, followed by filtration. The solvent was removed under reduced pressure, to thereby give 5-bromo-2-hydrazinopyridine as a solid (7.61 g, 96%).

Provenance & Evidence