Sodium Hydroxide → HCID 136339024, compound

Participants

Reaction Steps

To a solution of 1-[5-(4-benzyloxyphenyl)-1-(6-methoxy-3-pyridyl)pyrazole-3-carbonyl]-4-methylpiperazine (0.802 g) obtained in Example 18 in ethanol (15 mL), 10% palladium-carbon (0.466 g) and 1M HCl-ethanol (1.65 mL) were added, and the mixture was stirred at room temperature in a hydrogen atmosphere for 24 hours. After completion of the reaction, the atmosphere was changed to nitrogen, and the mixture was neutralized with aqueous sodium hydroxide. Insoluble matter was separated, and the residue was washed with methanol the filtrate was removed under reduced pressure, and the residue was partitioned between water and chloroform. Subsequently, the aqueous layer was extracted with chloroform. The organic layers were combined and washed with saturated brine, followed by drying over sodium sulfate anhydrate. After filtration, the solvent was removed under reduced pressure. The residue was purified through silica gel column chromatography (chloroform-methanol), to thereby give the title compound as a foamy substance (0.493 g, 69%).

Provenance & Evidence